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これまでの研究成果(論文)のご紹介

2025.04.01

「これまでの研究成果(論文)のご紹介-今後も研究成果を配信してまいります。」

当社代表が中心となって取り組んできた、医療用ヒドロゲルやカプセル化技術、その他の研究成果(論文)をご紹介します。今後もエビデンスを重視し、独創的な研究開発に専念するとともに、その研究成果を積極的に発信してまいります。


●Yamashita, Y., Hosoya, K., Fujiwara, Y., Saito, Y., Yoshida, M., Matsune, S., Okubo, K., Takei, T. Injectable chitosan hydrogel particles as nasal packing materials after endoscopic sinus surgery for treatment of chronic sinusitis. Gels, 11 (1), Article No.60 (2025).


●草野 奈央, 吉永 拓真, 清山 史朗, 吉田 昌弘, 武井 孝行. ベイズ最適化を利用したコアセルベーションマイクロカプセル調製条件の効率的最適化. 化学工学論文集, in press (2025年1月7日受理).


●Hosokawa, Y., Goshima, T., Kai, T., Kobaru, S., Ohzuno, Y., Nii, S., Kiyoyama, S., Yoshida, M., Takei, T. Preparation of alginate hydrogel beads on a superhydrophobic surface with calcium salt powder to enhance the mechanical strength and encapsulation efficiency of ingredients. Materials, 17 (24), Article No.6027 (2024).


●Yamashita, Y., Ohzuno, Y., Yoshida, M., Takei, T. Autoclaving achieves pH-neutralization, hydrogelation, and sterilization of chitosan hydrogels in one step. Macromol, 4 (2), 376–386 (2024).


●Yamashita, Y., Ohzuno, Y., Saito, Y., Fujiwara, Y., Yoshida, M., Takei, T. Autoclaving-triggered hydrogelation of chitosan-gluconic acid conjugate aqueous solution for wound healing. Gels, 9 (4), Article No.280 (2023).


●Takei, T., Tomimatsu, R., Matsumoto, T., Sreejith, K. R., Nguyen, N. T., Yoshida, M. Hydrophobically modified gelatin particles for production of liquid marbles. Polymers, 14 (22), Article No.4849 (2022).


●Evans, C., Morimitsu, Y., Nishi, R., Yoshida, M., Takei, T. Novel hydrophobically modified agarose cryogels fabricated using dimethyl sulfoxide. J. Biosci. Bioeng., 133 (4), 390–395 (2022).


●Evans, C., Morimitsu, Y., Hisadome, T., Inomoto, F., Yoshida, M., Takei, T. Optimized hydrophobically modified chitosan cryogels for strength and drug delivery systems. J. Biosci. Bioeng., 132 (1), 81–87 (2021).


●Takei, T., Yoshihara, R., Danjo, S., Fukuhara, Y., Evans, C., Tomimatsu, R., Ohzuno, Y., Yoshida, M. Hydrophobically-modified gelatin hydrogel as a carrier for charged hydrophilic drugs and hydrophobic drugs. Int. J. Biol. Macromol., 149, 140–147 (2020).


●Takei, T., Yamasaki, Y., Yuji, Y., Sakoguchi, S., Ohzuno, Y., Hayase, G., Yoshida, M. Millimeter-sized capsules prepared using liquid marbles: Encapsulation of ingredients with high efficiency and preparation of spherical core-shell capsules with highly uniform shell thickness using centrifugal force. J. Colloid Interface Sci., 536, 414–423 (2019).


●Yoshinaga, T., Nishimata, H., Tanaka, S., Hori, E., Tomiyoshi, A., Tokudome, E., Takei, T., Yoshida, M. Use of ANGPTL2 mRNA in formalin-fixed paraffin-embedded tissues as a biomarker to diagnose gastric cancer and evaluate the extent of vascular invasion. Oncol. Lett., 17 (1), 518–524 (2019).


●Yoshinaga, T., Niou, T., Niihara, T., Kajiya, Y., Hori, E., Tomiyoshi, A., Tokudome, E., Nishimata, H., Takei, T., Yoshida, M. Angiopoietin-like protein 2 is a useful biomarker for pancreatic cancer that is associated with type 2 diabetes mellitus and inflammation. J. Cancer, 9 (24), 4736–4741 (2018).


●Takei, T., Yoshitomi, H., Fukumoto, K., Danjo, S., Yoshinaga, T., Nishimata, H., Yoshida, M. Toxic chemical cross-linker-free cryosponges made from chitosan-gluconic acid conjugate for chondrocyte culture. J. Chem. Eng. Jpn., 50 (2), 142–148 (2017).


●Yoshinaga, T., Shigemitsu, T., Nishimata, H., Kitazono, M., Hori, E., Tomiyoshi, A., Takei, T., Yoshida, M. Angiopoietin-like protein 2 as a potential biomarker for colorectal cancer. Mol. Clin. Oncol., 3 (5), 1080–1084 (2015).


●Yoshinaga, T., Shigemitsu, T., Nishimata, H., Takei, T., Yoshida, M. Angiopoietin-like protein 2 is a potential biomarker for gastric cancer. Mol. Med. Rep., 11 (4), 2653–2658 (2015).


●akei, T., Aokawa, R., Shigemitsu, T., Kawakami, K., Yoshida, M. Fabrication of uniformly cell-laden porous scaffolds using a gas-in-liquid templating technique. J. Biosci. Bioeng., 120 (5), 577–581 (2015).


●武井 孝行, 中原 秀樹, 川上 幸衛, 吉田 昌弘. トレオン酸修飾キトサンおよびキシロン酸修飾キトサンの凍結-融解処理によるゲル化特性ならびに生物学的特性の評価. 科学・技術研究, 2 (2), 123–126 (2013).


●Takei, T., Nakahara, H., Tanaka, S., Nishimata, H., Yoshida, M., Kawakami, K. Effect of chitosan-gluconic acid conjugate/poly(vinyl alcohol) cryogels as wound dressing on partial-thickness wounds in diabetic rats. J. Mater. Sci. Mater. Med., 24 (10), 2479–2487 (2013).


●Takei, T., Nakahara, H., Ijima, H., Kawakami, K. Synthesis of a chitosan derivative soluble at neutral pH and gellable by freeze-thawing, and its application in wound care. Acta Biomater., 8 (2), 686–693 (2012).

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